Arsenal v Man Utd
Live on BBC One
Arsenal were superb in their 2-0 victory over Chelsea last weekend, discovering a diamond 4-4-2 formation that maximised the talents of their squad: Aaron Ramsey filled the Ozil-shaped hole in the number ten space; Granit Xhaka's simplified defensive midfield role kept him disciplined (and meant he could drop into a back three, giving the full-backs freedom to push on); and Lucas Torreira and Matteo Guendouzi excelled out wide, allowing Unai Emery to win the midfield battle with four central midfielders on the pitch.
As a bonus, both Alexandre Lacazette and Pierre-Emerick Aubameyang could play as strikers, negating their respective inability to contribute creatively. However, Manchester United are a far more varied, direct, and powerful opponent than Chelsea proved to be. The Gunners' return to a back four - coupled with the absence of wingers to provide defensive support to the full-backs - means they will be vulnerable to quick counter-attacks.
Paul Pogba and Marcus Rashford are developing a superb relationship under Ole Gunnar Solskjaer, a fact best highlighted by their combination for the winning goal at Spurs a fortnight ago. When this high-pressing United team win the ball, the direct route from Pogba to Rashford ought to beat a slow, weakened, and under-staffed Arsenal defence.
Man City v Burnley
Burnley may have won four of their last five matches, conceding just two goals in that time, but it is premature to assume their old resilience has returned; beating Huddersfield, Barnsley, West Ham and Fulham isn't a very big achievement. In fact, during that time they have continued to look defensively vulnerable, particularly in the right-back position.
Phil Bardsley failed to make a single tackle or interception in last weekend's 0-0 draw with Watford, but more importantly was unable to cope with the pace and directness of Arsenal's Sead Kolasinac and Alexandre Lacazette the last time Burnley faced a top side. Sean Dyche's narrow defensive blockade invites pressure, and any side capable of creating overlaps in the wide positions stands a good chance of getting to the byline.
Man City love to play through balls in between the full-back and centre-back, with the combination of David Silva to Leroy Sane arguably the best in Europe. Bardsley's one-on-one against Sane - back in form with three goals and four assists in his last five appearances - is a worrying prospect for Burnley fans.
Crystal Palace v Spurs
Live on BT Sport 2
Dele Alli's hamstring injury has left Mauricio Pochettino with very few options for this one; he could either start Georges-Kevin Nkoudou in a 4-3-3 or continue with the 3-4-3 used at Fulham, pushing Christian Eriksen into a more advanced role and starting Eric Dier in midfield. Either way, it'll no doubt lead to another awkwardly narrow Spurs display in which Harry Kane's creativity and goalscoring are sorely missed.
Fernando Llorente was dreadful at Fulham, consistently miscontrolling the ball until the Spurs players stopped attempting long passes into the penalty area. Without Kane dropping off and feeding the ball out wide, Spurs become overly narrow, with Eriksen and Erik Lamela dancing harmlessly in the centre of the pitch.
Tottenham's lack of urgency or movement means they will be bunched in the middle, and so the Palace barricade should easily absorb pressure. What's more, Tottenham's positional play will leave Danny Rose and Kieran Trippier with too much to do when the ball goes out wide, running into a two-man line of full-back and winger. Palace should hold firm.
Newcastle v Watford
Watford's 4-2-2-2 formation tends to leave too much space on the flanks during matches in which they dominate possession. The midfielders are expected to drop into winger roles when the ball is lost but fail to do so when the game is one-sided; Roberto Pereyra and Ken Sema begin to roam freely, opening up an opportunity for patient clubs likes Rafa Benitez's Newcastle.
In Newcastle's 1-0 victory over Watford in November Kenedy (set to return from injury this weekend) completed five dribbles and won the set-piece that led to the winning goal. In the reverse fixture, a 1-1 draw at Vicarage Road, Christian Atsu completed five dribbles from the same wing. What's more, Matt Ritchie assisted the Newcastle goal from left-back - a position he will most likely fill on Saturday.
Newcastle will probably target the left flank again, then, a prospect made more enticing by Kiko Femenia's absence through injury.