Premier League champions Manchester City will travel to West Ham in the opening round of Premier League 2022/23 fixtures.
It could be the day new signing Erling Haaland makes his debut for the Blues.
Nottingham Forest, who are odds-on for relegation, will play their first top flight match for 23 years at Newcastle.
The Magpies will be hoping to build on their excellent second-half of last season under Eddie Howe, while Forest manager Steve Cooper (pictured below) would love to come away frm St James' Park without losing.
Forest are 1.84/5 to be relegated, with only Bournemouth 1.728/11, who begin at home to Aston Villa on Saturday 6 August, a shorter price in the drop betting.
Fulham are next in the market at 2.285/4 and they are at home to Liverpool in the lunchtime kick off on the opening Saturday.
The Reds may have new striker Darwin Nunez in the line-up, so check out the new specials markets on his first season in English football.
The season will kick off at 8pm on Friday 5 August at Selhurst Park as Patrick Vieira's Crystal Palace host his old club Arsenal.
It will be completed by West Ham v Man City on Sunday 7th.
Manchester United fans will have to wait until the Sunday to see their team begin life under Erik ten Hag. They host Brighton who thumped the Red Devils 4-0 in their penultimate match last season.
We'll have betting previews of every match on Betting.Betfair.
Season like no other
This season will be different to all others due to the winter World Cup in Qatar which starts on 21 November and concludes on 18 December.
Prior to the World Cup, there are no meetings between the Premier League's so-called 'big six' on weekend 12-13 November, following a request by the Football Association.
The Premier League will then be suspended until fixtures resume on Boxing Day.
Premier League 2022/23 Gameweek 1
Friday, 5 August
Crystal Palace v Arsenal (20:00 BST)
Saturday, 6 August
Fulham v Liverpool (12:30)
Bournemouth v Aston Villa (15:00)
Leeds United v Wolverhampton (15:00)
Leicester City v Brentford (15:00)
Newcastle United v Nottingham Forest (15:00)
Tottenham Hotspur v Southampton (15:00)
Everton v Chelsea (17:30)
Sunday, 7 August
Manchester United v Brighton (14:00)
West Ham United v Manchester City (16:30)