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Favourites City get Spurs in R4
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Emery's Villa go to Pochettino's Chelsea
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Man Utd to face L2 or National League team
Manchester City are the 4.57/2 favourites on the Betfair Exchange to win the FA Cup but to do so they will have to end their run of defeats at the Tottenham Hotspur Stadium in round four.
Pep Guardiola's treble winners have lost on all five of their visits to Spurs' new home. The teams drew 3-3 at Etihad earlier this season and the contest between Guardiola and Ange Postecoglou's men is the standout tie of the round that will be played across the weekend of 27 and 28 January.
Tottenham are 13.525/2 in the outright winner market, after beating Burnley in round three, but Postecolgou has cup pedigree, winning three with Celtic, and had plenty of support from bettors before the competition kicked off.
Liverpool are 5.24/1 and their reward for beating Arsenal in the third round is an Anfield date with Norwich City or Bristol Rovers.
Round 4 draw throws up all-Premier League ties
In other all-Premier League round four meetings, Chelsea will host title contenders Aston Villa, Newcastle will go to Fulham and Sheffield United will welcome Brighton.
West Ham and Nottingham Forest will play each other if both win their third-round replays. If Luton beat Bolton they will go to Crystal Palace or Everton.
Man Utd to visit Newport or Eastleigh
Manchester United are 10.519/2 third favourites after they beat Wigan to book a fourth round trip to League Two Newport or non-league Eastleigh.
Diogo Dalot and Bruno Fernandes scored for the Red Devils who passed a tricky test against their League 1 opponents.
Last season, United reached the final of the FA Cup before losing to local rivals City, and Erik ten Hag's decision to field his strongest 11 against Wigan indicates that he knows the FA Cup is United's best chance of giving their fans something to celebrate this season.
Maidstone United are the lowest-ranked club left in the cup will visit Championship promotion contenders Ipswich.
FA Cup round 4 draw in full
Watford v Southampton
Blackburn Rovers v Wrexham
Bournemouth v Swansea City
West Brom v Brentford or Wolves
West Ham or Bristol City v Nottingham Forest or Blackpool
Leicester City v Hull City or Birmingham City
Sheffield Wednesday v Coventry City
Chelsea v Aston Villa
Ipswich Town v Maidstone United
Liverpool v Norwich City or Bristol Rovers
Tottenham Hotspur v Manchester City
Leeds United v Plymouth Argyle
Crystal Palace or Everton v Luton Town or Bolton Wanderers
Newport County or Eastleigh v Manchester United
Sheffield United v Brighton & Hove Albion
Fulham v Newcastle United