"Leipzig have won every game they've played since the first leg, and their group-stage win over Manchester United shows they can perform under pressure."
Get our football experts' best bets for the midweek action in the Champions League, Premier League and English Football League...
There'll be no remarkable comeback this time as the visitors seek to achieve the impossible on Wednesday night, argues James Eastham in his preview.
He says: "Barcelona need to score four goals to stand any chance of making the impossible happen. In the end, it seems inevitable that this will end up an open game, leading to chances at both ends."
Back PSG vs Barcelona Over 3.5 Goals @ 2.111/10
Out-of-form Liverpool are 2-0 up from the first leg of their Champions League tie with RB Leipzig, but our Bundesliga expert Kevin Hatchard thinks the Germans will give them a scare.
He says: "Leipzig have won every game they've played since the first leg, and their group-stage win over Manchester United shows they can perform under pressure."
Back RB Leipzig/Draw Double Chance and Over 1.5 Goals at 1.8810/11
In the Premier League leaders Man City try to return to winning ways when they host Southampton on Wednesday evening and Dan Fitch has previewed.

He says: "Southampton have failed to score in five of their last seven away games in the Premier League."
Back Manchester City to beat Southampton to nil at 1.9520/21
UEL favourites Manchester United face a glamour tie against Milan and Kevin Hatchard believes they'll make a strong start.
He says: "Milan's form has dipped as they move into the home stretch of a demanding season, while United have the resources to fight on multiple fronts."
Back Manchester United to win and Under 3.5 Goals at 2.285/4
Arsenal were dumped out of the Europa League by Olympiakos last season, and Kevin thinks the Greek champions can cause problems again on Thursday.
He says: "Olympiakos are used to winning domestically, and they knocked out a decent PSV side in the previous round. Arsenal dug themselves out of trouble against Benfica, but their inconsistency makes them poor value at odds-on."
Lay Arsenal at 1.9720/21
Kevin makes four more picks from the best of the rest of the Europa League action featuring a certain England striker.
He says: "Kane is in sparkling form, and is expected to start as Tottenham look to take a decisive step towards the quarter-finals."
Back Tottenham to win and Harry Kane to score v Dinamo Zagreb at 1.9210/11
The newly-crowned champions of Scotland travel to Prague following a weekend of celebrations. Frankie Monkhouse takes a sobering look at their chances.
He says: "It's understandable that Slavia are favourites as they have home advantage and are filled with confidence following that deserved victory over a strong Leicester team last time."
Back The Draw @ 3.412/5