Tottenham v Wolves (12:30) - Harry in a hurry
It is doubtful that Wolves' new signing Matheus Nunes will feature from the start in the capital but at least a cameo from the bench will be a source of some excitement for their long-suffering fans who have seen their team now go nine without a win.
Since beating Villa at the start of April, Bruno Lage's men have scored every 135 minutes and conceded every 45 minutes.
A failure to buy lottery tickets is the chief reason for their woes, with only relegated Watford and Norwich taking on fewer shots last season.
Chancing their arm in sight of goal is certainly not a problem for Spurs - as our latest Hot and Cold column shows - and more specifically Harry Kane. Indeed, since Antonio Conte has taken charge no other player has had more shots in the Premier League (119).
It should concern the visitors too that Kane has fired four in eight against them previously.
A reminder that Spurs v Wolves is a Bet 5 Get 5 Fixture, meaning if you place a £5 free bet on any Bet Builder before the match, you can get a £5 free bet.
Crystal Palace v Aston Villa (15:00) - Mings the merciless
Villa are better on their travels under Steven Gerrard than at home and with one of their 43% of successes taking place at Selhurst Park last November, perhaps they can approach this game with some degree of confidence.
Just two clean sheets in their last 13 outings however, chips away at that fragile conviction, and with a mini-injury crisis at the back depriving them of new boy Diego Carlos and the eternally under-rated Matty Cash, it's a belief that flounders.
Discipline is of interest here with the Villans being villains all of last season, racking up the second highest caution count, and with seven bookings to their name already in 2022/23 it seems lessons have not been learned.
No player saw yellow more often than Tyrone Mings last term - take note Souness - and this Saturday afternoon he will have Eze and Zaha running at him for 90 minutes straight, as highlighted by Alex Keble in his Acca Builder.
Everton v Nottingham Forest (15:00) - Tricky Trees to fall
Having to adapt to a higher level, all while assimilating several new players makes Forest an unpredictable entity at present, but it's fair to say they looked a different proposition last weekend to the team that was so passive and uncertain at St James Park on the opening day, failing to post even a single shot on target.
Against West Ham, Steve Cooper's men far better resembled the side who successfully navigated the Play-Offs back in May, through strength of character as much as aptitude.
Yet as memorable as their first Premier League win in 23 years was last Sunday, Forest definitely rode their luck versus the Hammers and it's extremely telling that no other side have faced more shots from their first two games.
The Toffees will be desperate not to lose their opening three matches - something they last did 32 years ago - and this desperation gives them the edge here, especially if Forest turn passive again on the road. A tight home victory is the way to go.
Fulham v Brentford (15:00) - A tale of two forwards
A missed pen and an otherwise unremarkable display at Wolves may have tempered the hype around Aleksandar Mitrovic's quest to prove he is Premier League prolific but that shouldn't detract from his phenomenal record at Craven Cottage.
Going all the way back to early August last year, the serious Serb has scored on home soil every 77 minutes. As stated, that's phenomenal.
If the 27-year-old is a huge advantage for the Cottagers, elsewhere history counts against them having failed to win a top-flight London derby now in 24 attempts. Brentford's outstanding form, meanwhile, that dates back to early March, is also quite clearly a hindrance.
In Ivan Toney, the Bees have their own goal-machine and with a goal and two assists already, the usually streaky striker is starting early this year.
What most stands out from his most recent haul is that only one from his previous nine have been converted in the first half.
Leicester v Southampton (15:00) - Hot and cold vs hot and cold
Perhaps the Foxes second-half implosion at home to Brentford on day one shouldn't have overly surprised given that last season, Brendan Rodgers' side relinquished leads on nine occasions.
Surprise though it did because in the first-half against the Bees, Leicester looked so in control. And then suddenly they really weren't.
It was in part a similar tale at the Emirates last week, with Vardy and co vibrant in patches, but elsewhere all at sea, and this might well be a pattern that persists throughout their campaign, as consistency eludes them.
If Leicester are to be inconsistent, the Saints will no doubt ask them to hold their beer. A late flourish v Leeds last Saturday came out of nowhere but even their two-goal fightback was not enough to address a worrying and sustained slump that has seen them win only once in their last 14.
To their slight credit, at least Southampton have only failed to score four times during this bleak period.
Bournemouth v Arsenal (15:00) - Don't pick the Cherries
This feels like a defining fixture for the Cherries who have so far been Hyde, then Jekyll, with an impressive performance in beating Villa on the opening day giving way to a cowed display at the Etihad, an acceptance of their inferiority that did them no favours.
So, what now for Scott Parker's side? Will we see the Bournemouth who boasted the meanest defence in the Championship last term, while scoring 74 times into the bargain? Or a team compliant in being outclassed?
They will likely struggle against a Gunners collective who crucially have their Gabriels bang in form.
Martinelli has scored for two games running while Jesus was everything to Arsenal's expansive victory last weekend. The former City striker has yet to lose a league game in which he has notched, a tally that now stands at 48.