Schrodinger's Cat has done nothing but improve since joining Grant Tuer this season, having excuses the only time he has finished out of the money, and he looks capable of another bold bid in Ascot's opener.
He easily opened his account for his current stable at Redcar in June and took another step forward from an 8 lb higher mark when touched off at York by another progressive type, Naana's Shadow, just a week later.
While Naana's Shadow runs in listed company at York later in the afternoon, Schrodinger's Cat is 3 lb clear in the Timeform weight-adjusted ratings here and has the 'Horse In Focus' flag from his last start.
Back Schrodinger's Cat in the 13:55 at Ascot
Machadadorp has made a promising start to her career for 'Hot Trainer' Andrew Balding, and she looks capable of completing a hat-trick of wins under Oisin Murphy going into handicaps for the first time.
Thrown in the deep end at Ascot on her debut, she was much improved when getting off the mark in a maiden at Chester in May and then followed up with a narrow win over Rogue Invincible in a novice at Wetherby.
Machadadorp was given the 'Horse In Focus' flag for that success, with the runner-up franking that form with a win of his own earlier in the week, and she heads the Timeform weight-adjusted ratings.
Back Machadadorp in the 14:15 at Newmarket
Roger Varian has won the John Smith's Cup twice, most recently in 2024 when Enfjaar beat stablemate Botanical, and the 'Hot Trainer' has a strong candidate again this year with Raammee.
The lightly-raced four-year-old won both his novices last year, bolting up by a dozen lengths at Newcastle on the second occasion, and has shown useful form again in a couple of handicaps at Sandown this year.
He earned the 'Horse In Focus' flag last time when a keeping-on second to another progressive type, Beagle Bay, and heading the Timeform weight-adjusted ratings he can improve again stepping up in trip.
Back Raammee in the 15:45 at York