Manchester City have shortened to 3.814/5 favourites to win this season's FA Cup after being drawn at home to Championship side Fulham in round four.
In a particularly kind draw for the Premier League's big clubs, Chelsea, Liverpool and Tottenham, plus Manchester United should they progress, were also drawn to play at home in the next round.
Chelsea can be backed at 7.26/1 and will host League One outfit Plymouth at the beginning of February, while Liverpool 8.415/2 will be at home to Championship strugglers Cardiff City.
Mann Utd and Tottenham are both trading at around the 13.012/1 mark and will host Middlesbrough and Brighton respectively in round four (should United progress).
Mixed draws for giantkillers
Two of the third round headline grabbers, Kidderminster Harriers and Cambridge United, were both drawn at home though it's the former who will be licking their lips at the prospect of hosting Premier League big boys West Ham in the next round.
Although by no means a glamour tie League One side Cambridge will fancy their chances of reaching round five after being drawn at home to Championship outfit Luton Town.
Large number of Premier League clubs fancied to progress
As well as the big five already mentioned, the likes of Wolves, Everton, Crystal Palace and Southampton were also handed home ties in the next round meaning that there's a strong possibility of a big representation of Premier League clubs progressing to round five.
The draw was also far from kind to National League outfit Boreham Wood who were draw away to Championship league leaders Bournemouth, while Arsenal's conquerors in Sunday's late game, Nottingham Forest, will host Premier League outfit Leicester.
FA Cup Fourth Round draw in full:
*Premier League teams in bold
Crystal Palace v Hartlepool
Bournemouth v Boreham Wood
Huddersfield v Barnsley
Peterborough v QPR
Cambridge United v Luton
Southampton v Coventry City
Chelsea v Plymouth Argyle
Everton v Brentford
Kidderminster Harriers v West Ham
Man Utd or Aston Villa v Middlesbrough
Tottenham v Brighton
Liverpool v Cardiff City
Stoke v Wigan
Nottm Forest v Leicester
Man City v Fulham
Wolves v Norwich
*ties to be played weekend commencing Friday 4 February
Get a Free £10 Bet - Every Day!
From January 7-13, we are Doubling our Daily Rewards! Stake £20 on Multiples or Bet Builders over the course of a day, and, after the bets have settled, you'll get a free £10 bet to use on Multiples or Bet Builders. Bets must settle within 48 hours. No opt-in required, T&Cs apply.