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Shakhtar underrated
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Barcelona will extend unbeaten record
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Crvena Zvezda will pick up first points
Antwerp v Shakhtar (Wednesday, 17:45)
Both Antwerp and Shakhtar suffered defeat in their opening games in Group H.
Antwerp were thrashed 5-0 away at Barcelona. Since that loss, Mark van Bommel's side have drawn three consecutive games 0-0, leaving them in fifth position in Belgium's First Division A.
Shakhtar were also well beaten in their opener. Porto were 3-1 up at half-time against the Ukrainians and that ended up being the final score. Realistically, it would seem that these teams will be competing for third place and Europa League qualification, with Shakhtar having the disadvantage of having to play their 'home' games on neutral turf.
Antwerp are rated as odds-on favourites to win this, which seems a bit of an overreaction to their own home advantage, especially considering their run of goalless draws. Back Shakhtar double chance combined with under 4.5 goals, at odds of 11/82.38.
Porto v Barcelona (Wednesday, 20:00)
We have another Group H clash later on Wednesday, when Porto host Barcelona.
With this game likely to be Barcelona's most challenging fixture, a good result for Xavi's team, would put them in the driving seat. They beat Sevilla 1-0 over the weekend, maintaining their unbeaten start to the season across all competitions (P9 W7 D2).
Porto have lost twice so far this season (P9 W6 D1 L2), with both of those defeats coming against their rivals Benfica. The latest loss came on Friday night when Benfica beat them 1-0, though they were at a big disadvantage for much of the game, after Fabio Cardoso was sent off after 19 minutes.
Barca have drawn two of their four away games this season (W2), so odds of 4/51.80 for an away victory look a little slim. Instead, go for Barca double chance and over 2.5 goals at 23/202.15.
Crvena Zvezda v Young Boys (Wednesday, 20:00)
Over in Group G, Crvena Zvezda and Young Boys are both looking for their first points.
This is another group where the identity of the top two looks set in stone, with the Champions League holders Manchester City and RB Leipzig leading the way. In the first round of fixtures, City beat Crvena Zvezda 3-1 at home, while Leipzig won by the same scoreline at Young Boys.
Crvena Zvezda are well rested since that match, with their 1-0 weekend win over Radnicki Nis being their only outing. Young Boys have played three times in that period, beating Lugano and Grasshoppers, either side of an away defeat to St. Gallen.
With these sides likely to be competing for a Europa League spot, there is a lot riding on this match. A raucous atmosphere, should help the hosts' quest for points. Back Crvena Zvezda double chance, with both teams to score, at odds of 10/111.91.