The Dragons welcome back James Collins, though will be without the suspended Craig Bellamy and David Vaughan, while doubts remain over Jack Collison. Darren Bent and Micah Richards are the only absentees for the Three Lions, having withdrawn from the squad over the weekend.
England appeared invigorated against Bulgaria with a youthful line-up and balance to the formation. Scott Parker and Gareth Barry holding in midfield offered greater confidence for the front four - headed by the vivacious Wayne Rooney - and the performance spoke volumes, albeit against poor opposition.
The only points dropped by Capello's men during European Championship qualification came at home, with draws against Montenegro and Switzerland. Indeed, England have not won any fixture at Wembley since beating Bulgaria 4-0 in the opener last September - drawing three and losing one.
Regardless, Wales do not have enough to deny England a fifth group win and certain qualification. The side have shown signs of improvement under Gary Speed - with two wins from six - but they have lost 12 of their last 15 fixtures over all, which explains their FIFA world ranking of 117.
Recent encounters between the teams offer little encouragement for the visitors, with the hosts winning each the three matches played this century - twice in Cardiff. The result of this match should be in little doubt with the expected England win at 1.162/13, a shock Wales victory at 27.026/1 and the Draw 9.617/2.
Wales have conceded 19 goals in their last ten fixtures - beaten by two or more on five occasions during that period. England, meanwhile, have won five of their last eight competitive games at Wembley by at least three goals. England with a -2.5 goal Asian handicap trades at 2.03103/100 and offers some value.
All but three of Fabio Capello's 18 home games in charge of England have delivered in excess of two goals, with nine of these seeing four goals or more. Yet, the Three Lions have kept just six clean sheets at Wembley under the Italian, conceding in half of their eight tournament qualification matches.
over 2.5 Goals is available at a skinny looking 1.548/15, though there should be greater appeal in taking over 3.5 goals at 2.3411/8. There may also be reward from backing Both Teams to Score at 2.56/4. Meanwhile, a 3-1 and 4-1 Correct Score can be snapped up at 13.525/2 and 15.529/2 respectively.
England will seek to put Wales on the back foot from the outset and much like the reverse fixture back in March, an early goal could be likely. 0-10 minutes and 11-20 minutes may tempt in the first goal odds market at 3.55/2 and 4.57/2.
Currently in the form of his career, Manchester United new boy, Ashley Young, was England's chief tormenter at the Millennium Stadium and offers an attractive option to be the game's first goalscorer at 6.05/1.
The follicly-replenished Wayne Rooney has instantly found the same wavelength as the former Villa forward at club level, and has developed Samson-like powers over the summer. A brace in Sofia handed him his first England goals for a year and he may well seek more, with a hat-trick scored on offer at 7.613/2.
Wales will need their big name players to perform if they are to salvage any pride from this contest. Gareth Bale did not face England earlier in the year and will provide the away side's most likely chance of finding the net. Tottenham's jet-heeled winger is 8.07/1 to score.
Best Bet
Over 3.5 Goals @ 2.3411/8
Recommended Bets
Both Teams To Score @ 2.56/4
0-10 Minutes First Goal Odds @ 3.55/2