Giovanni Trapattoni's side won 2-1 when the sides met in Dublin in March, although Macedonia produced a dominant second-half performance in which they came close to earning a point.
The group table may show the Republic are significantly superior - they head the pool with 10pts from five games, while the hosts have 4pts from five games so far - but there was enough in that head-to-head clash to suggest the hosts deserve supporting at the available prices this weekend.
Mirsad Jonuz's side are 3.8514/5, with the visitors 2.245/4 and the draw 3.3512/5. I'd recommended laying the Republic or backing the draw as the game comes at the end of a long season for most of the visiting players.
For a second bet, consider backing both teams to score. Republic of Ireland have struggled to keep clean sheets: they've conceded in four of five games, with their only 'to nil' performance coming in their opening match in Armenia nine months ago. Macedonia have also conceded in four of five games to date.
The likelihood of both teams scoring and the draw occurring suggests 1-1 is your best correct-score selection.
Best Bet: Back the draw @ 3.3512/5.
Other Recommended Bet: 'Yes' in Both Teams to Score? Market @ 1.9310/11.