If there was any doubt who the big dogs in the NFL were then the San Francisco 49ers whalloping Dallas showed exactly why they're the 4/15.00 Super Bowl favourites.
The Eagles are the only other team to match San Francisco's 5-0 start ahead of their week six trip to the New York Jets, while the third and final London game sees the Ravens face the Titans.
Buffalo and Jacksonville are both in action a week after the Jags won at Spurs, so it'll be interesting to see how jet lag plays a part there.
NFL Week Six Schedule
Baltimore Ravens (3-2) @ Tennessee Titans (2-3)
Match Odds: 1/21.50 | 8/52.60
Points Spread: Ravens -4
Total Over/Under: 41
Both teams arrive in London after a loss, with Baltimore in particular fuming after somehow allowing the Steelers to win a game they were never really in.
The Titans are a tough team to get a handle on, as shown by them alternating wins and losses this season - and by that streak they're due a win as outsiders at Tottenham.
A game across the Atlantic between two low-scoring teams means we're not expecting a barnburner, more an armwrestle on the ground as the Titans try to get Derrick Henry going.
The Titans give up plenty of yards in the air though so Lamar Jackson would be wise to air it out and let his receivers redeem themselves after a woeful effort in Pittsburgh - where they dropped five passes, the most in the NFL in a single game this season.
San Francisco 49ers (5-0) @ Cleveland Browns (2-2)
Match Odds: 2/91.22 | 7/24.50
Points Spread: Niners -9.5
Total Over/Under: 35.5
Brock Purdy and San Francisco's perfect record faces a tough test in the league's best defence awaiting in Cleveland having had a bye week off to prepare.
It's another threat to San Francisco's streak of eigth straight 30-point games, but they may not need 30 this time around with the Browns again missing QB Deshaun Watson.
You can't really run on the Niners either, so only Myles Garrett and a Browns defence that's only given up five TDs this season can keep this close - as an early 49ers lead could open the floodgates.
Philadelphia Eagles (5-0) @ New York Jets (2-3)
Match Odds: 4/111.36 | 11/53.20
Points Spread: Eagles -6.5
Total Over/Under: 41
The perfect Eagles also have a perfect 12-0 record against the Jets, which doesn't look like ending this year as they're big favourites in the Big Apple.
Keeping Zach Wilson off his backside without their best lineman looks a tougher task for the Jets offence then trying to stop the Eagles doing their "tush push" is for the defence.
This will be all about the run - the Jets are the only team in the league that averages more yards per rushing play than passing, so it's clear what their gameplan will be.
Philly can run it though, and the Jets being the second-worst team in the league defending rushing QBs will see Jalen Hurts' eyes light up.
Carolina Panthers (0-5) @ Miami Dolphins (4-1)
Match Odds: 13/27.50 | 1/101.10
Points Spread: Dolphins -14
Total Over/Under: 47.5
It get no easy for the winless Panthers who visit the team with the most yards in history after five games - and with possibly three starters missing from thier secondary.
Carolina also don't stack up well against the run and against this offence that's a recipe for disaster - as Miami will beat you through the air and on the ground.
Tyreek Hill could have another big game, but without rookie star running back De'Von Achane, Raheem Mostert will capitalise and with seven TDs already and two multiple score games he can fill his boots with some extra touches.
Seattle Seahawks (3-1) @ Cincinnati Bengals (2-3)
Match Odds: 5/42.25 | 4/61.67
Points Spread: Bengals -2.5
Total Over/Under: 45.5
Joe Burrow and Ja'Marr Chase finally hooked up last week, but that Burrow calf will be tested against a rested and revived Seahawks squad that was last seen dishing out 11 sacks on the Giants.
Cincy are making a move but Seattle could just be the wrong team for them right now and at the prices I fancy the road team to score an 'upset' win.
The Bengals not being great against the run won't help - especially with Kenneth Walker, who has a TD in 14 of his last 16 games, going up against a unit that's allowed a rushing score in four of five this year.
Minnesota Vikings (1-4) @ Chicago Bears (1-4)
Match Odds: 4/61.67 | 5/42.25
Points Spread: Vikings -3
Totals Over/Under: 44
Things are finally looking up for the Bears after DJ Moore's explosion, while the Vikings are on the ropes after Justin Jefferson's injury blow - so I actually fancy Chicago as home underdogs.
It's not with a ton of confidence as the Vikings keep getting involved in tight games - and it's still the Bears - but Justin Fields has been getting his act together, throwing 617 yards these last two games.
So we'll show a little faith in him here.