NFL Week 5 Betting Tips and Predictions: Chiefs to win high-scoring game

NFL Week Five betting tips
NFL Week Five betting tips including the London game at Tottenham

Paul Higham returns with his week five NFL betting preview as big guns Dallas and San Francisco collide after the Bills face the Jags in London...

Week five already! This NFL season is motoring along and we're slowly starting to see just how is in it for the long haul and who is very much struggling already.

The Philadelphia Eagles and San Francisco are the only unbeaten sides while Carolina and Chicago remain winless and already starting to figure out how to plan for next season.

Week Five sees the Buffalo Bills head to London to face the Jacksonville Jaguars, the Eagles facing a big test in LA while the big game of the weekend is a big-time clash between historic NFC rivals the Cowboys and 49ers in San Francisco.

NFL Week 5 schedule

Jacksonville Jaguars (2-2) @ Buffalo Bills (3-1)

Match Odds: 9/52.80 | 4/91.44
Spread: Bills -5.5
Points O/U: 48.5

Buffalo are down at the 'home' team but the Jags have the advantage of having played, and won, in London last week so it'll be interesting to see if that helps them slow down Josh Allen and company.

It's the first time a team has played back-to-back in London, while we never know how players will react to the transatlantic journey - but the way Buffalo put away high-flying Miami last week was really impressive.

Trevor Lawrence hasn't his the heights expected and both he and Allen will have to work against two tough defensive units who get after the QB and disrupt the backfield.

The Jags to cover is tempting given the travel advantage, but you're playing a hunch then rather than facts - with the fact being Buffalo is a better team right now and can win what should be a defensive arm wrestle.

And on player props, Allen will need to take off given he;ll be under pressure, while the Fins blew up Buffalo on the ground game as Travie Etienne gets a ton of carries for the Jags.

So back Allen for 40+ and Etienne 60+ rushing yards in Bet Builder double of around 4/15.00.

Back Buffalo to beat Jacksonville & under 48.5pts @ 13/82.63

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Dallas Cowboys (3-1) @ San Francisco 49ers (4-0)

Match Odds: 6/42.50 | 8/151.53
Spread: Niners -3.5
Points O/U: 45

The game of the week hereas two historically great franchises clash in a blockbuster that will go a long way to settle just what the NFC playoff picture looks like.

The 49ers look like the best team in the league right now, but if Brock Purdy does come unstuck it'll be against this Cowboys defence that's forced a league-high 10 turnovers this season.

In Micah Parsons and Nick Bosa we have two of the biggest defensive animals in the NFL and either could wreck the game - but the big difference here could be in the red zone, where Dallas rank 30th offensively.

If Dak Prescott can't put up points if and when they get there, then Dallas won't be able to keep up with an offence that's scored 30 points in seven straight regular season games.

Nick Bosa to get 1+ sack & 49ers to win @ 6/52.20

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Kansas City Chiefs (3-1) @ Minnesota Vikings (1-3)

Match Odds: 8/151.53 | 8/52.60
Spread: Chiefs -3.5
Points O/U: 52.5

The Vikings are the only NFL team Patrick Mahomes hasn't beaten - because this is the very first time he's suited up against them.

Kirk Cousins leads the league with 11 TD throws and Mahomes hasn't been at his best with interception problems and struggles bedding in a new receiver group - Travis Kelce apart.

KC will struggle to contain Cousins and Justin Jeffersen so there's the hint of an upset here, but even in this NFL it's tough to imagine the champs not being able to win a shootout here.

Chiefs to win & over 52.5pts @ [13/]8]

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Baltimore Ravens (3-1) @ Pittsburgh Steelers (2-2)

Match Odds: 1/21.50 | 17/102.70
Spread: Ravens -4.5
Points O/U: 38

John Harbaugh and Mike Tomlin have been leading these bruising encounters for years and this time it's Pittsburgh who look in a spot of bother even with Kenny Pickett saying he can play.

Pittsburgh's defence is allowing the third-most yards and fourth-most passing TDs this season so they look tailormade for Lamar Jackson to have a big day - even with his poor record against the Steelers.

Pittsburgh are at home by so wildly unpredictable that you've got to fancey Baltimore to take control of the AFC North here.

Lamar Jackson to score & Ravens win @ 11/53.20

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Chicago Bears (0-4) @ Washington Commanders (2-2)

Match Odds: 21/10 | 2/51.40
Spread: Commanders -6
Points Over/Under: 44.5

It's now a team record 14 defeats in a row for the Bears after they blew a 21- point lead against Denver last week, so Washington should be licking their lips here after they pushed Philly all the way.

Chicago are showing some signs of life on offence and I don't think Washington are the type of team to win a blowout but they should win by a touchdown or so.

Justin Fields is coming off his best passing day in his career and Sam Howell was slinging it against the Eagles so expect some decent numbers off the quarterbacks.

Their two wide receivers should get plenty of action and I don't think either defence can prevent them getting into the end zone so a nice TD double I like for this one is Terry McLaurin and DJ Moore both to score at around 7/18.00.

Back Washington to beat Chicago by 1-13pts @ 11/102.11

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