Novak Djokovic 3.55/2 is the favourite to win the US Open, which begins at Flushing Meadows on Monday (27 August). Bettors are backing the Serbian to follow up his recent victory at Wimbledon with what would be a fourteenth Grand Slam of his career.
You won't be surprised to see that Rafael Nadal and Roger Federer follow Djokovic in the betting, as the Big Three - who between them have won the last seven Grand Slams - look set to dominate at the year's final Slam.
Favourite could meet Federer in quarter-finals of men's draw
If Djokovic is to win a third US Open title then he might have to get past Roger Federer in the quarer-final. Djokovic plays Marton Fucsovics in the first round and should have a fairly comfortable route through the first week of the tournament.
In the last eight, though, Federer could be waiting. The Swiss has won this Grand Slam at staggering five times and is 6.86/1 to add a sixth title this time. If the pair do meet then it has the potential to be the match of the tournament.
Mind you, Federer looks set to face a tougher opening week then Djokovic, as the Swiss player could be destined to meet Nick Kyrgios - a 60.059/1 outsider for the title but a tough oponent nevertheless.
Rafael Nadal 4.47/2, who is the defending champion, will be confident of beating countrymen in round one, although fifth seed Kevin Anderson might be waiting in round three.
Serena and Venus set for third round clash in women's draw
One thing is for sure - Serena Williams would love to win her first Grand Slam after becoming a parent in her own back yard of the US of A.
Bettors believe she has a good chance and make the five-time US Open champion 7.06/1 favourite in the women's draw betting. Serena begins her campaign against Poland's Magda Linette.
That contest should go smoothly for the American, but Serena could face sister Venus in round three (although you'd expect the younger Williams to win that one too).
World number one Simona Halep would love to win at Flushing Meadows for the first time (her previous best was reaching the 2015 semi-final. Bettors make her 7.87/1 to go all the way ahead of her opening match against Camila Giorgi of Italy.
Defending champion Sloane Stephens 10.519/2, meanwhile, plays Evgeniya Rodina in her first round match. Wimbledon Champion Angelique Kerber is 8.88/1 third favourite to win a consecutive Grand Slam and shouldn't have any trouble getting past Margarita Gasparyan in the first round.