Already a dual Group Two winner in America, Grandeur won at Listed level in Britain for a second time when beating Modernstone in the Winter Derby Trial over this course and distance last month.
Modernstone, trained by William Knight, is in the field along with Anaconda and Robin Hoods Bay, who were third and fourth that day.
Last year's winner Farraaj and the veteran Premio Loco, who was successful in 2012, are set to try again, while there are several other smart sorts including Dick Doughtywylie, Graphic, Highland Knight, Rebellious Guest and Godolphin's Windhoek.
The sole Irish representative is Jim Bolger's Parish Hall, who showed he still retains plenty of ability despite his problems when fourth in the Irish Champion Stakes at Leopardstown in September and winning the Group 3 Diamond Stakes the following month.
Grandeur tops Timeform's weight-adjusted ratings for the Winter Derby and is currently trading as favourite, available to back on Betfair at [2.54]. His chief market rival appears to be last year's winner Farraaj who is currently [7.4] second favourite on Betfair.