Tottenham v Manchester United
Live on Sky Sports 1
Match Odds: Tottenham 2.01/1, Manchester United 4.47/2, The Draw 3.711/4.
This clash at White Hart Lane is crucial for both sides, with Tottenham still in the running for the title and Manchester United challenging for the Champions League places. There's also still an outside chance they could end up fighting one another directly in the table - if United won here, and also won their game in hand, they'd be only three points behind.
Mauricio Pochettino's side start as strong favourites, however, and while the Argentine coach has rotated effectively this season, he's named a more consistent side now Tottenham have no other commitments and can concentrate on the league.
Therefore, it's unlikely there will be any significant changes here. Erik Lamela missed last weekend's draw at Liverpool and should return in place of Son Hueng-min, but otherwise expect the same side.
Jan Vertonghen is back in training but unlikely to be risked, so Kevin Wimmer will continue alongside Toby Alderweireld. The rest of the side picks itself.
Louis van Gaal's side is also unlikely to feature many changes from last weekend's somewhat uninspiring 1-0 victory over Everton.
One possible switch is at left-back, where Marcos Rojo was withdrawn at half-time last weekend after a poor performance, and replaced by the promising youngster Timothy Fosu-Mensah. Van Gaal has repeatedly thrown youth players into big matches this season, and might do the same again here. Rojo could get a reprieve, meanwhile, if left-sided centre-back Daley Blind fails to recover from a slight injury he collected in the final ten minutes against Everton.
The most interesting battle here will be down the flanks, where Spurs' attacking full-backs could cause United serious problems. In particular, it's likely that right-back Matteo Darmian will be dragged inside by the intelligent drifts of Christian Eriksen, which will open up space for the speedy Danny Rose to overlap into. United's right-sided midfielder, Juan Mata, isn't the most diligent player defensively, and Rose could be afforded lots of space.
On the opposite side, Kyle Walker will attempt to do something similar, but will probably be pinned back by the pace of Anthony Martial. If he does advance, expect Eric Dier to move towards the right into a covering position.
Spurs will also look to attack quickly in behind United's defence. Van Gaal likes playing with a high defensive line, but this could leave United exposed to the runs of Harry Kane, whose pace is often underestimated.
It's also worth considering that Dele Alli makes lots of runs in behind the opposition defence from his advanced midfield role, often to collect long Alderweireld diagonal balls. United have sometimes attempted to man-mark in midfield under Van Gaal, but it will be tough for Michael Carrick or Morgan Schneiderlin to track Alli's runs all the way.
Carrick and Schneiderlin may also struggle against Tottenham's quick press. Both players need time on the ball to play good passes out to the flanks, and might be caught out by Spurs' usual energetic start to matches.
United may cause problems with the pace of Marcus Rashford, who will look to run in behind Alderweireld and Wimmer, and Martial. It remains to be seen whether they can involve their attacking midfielders regularly, however: Spurs press so well, and remain so compact, that penetrative forward passes are extremely difficult. Mata might find more space on the right than in his preferred central role, although central attacking midfielder Jesse Lingard will struggle to see much of the ball against Dier and in-form Mousa Dembele.
United like dominating possession - but Tottenham's pressing could overwhelm them, and the home side are likely to create more chances here.