This is by far Chelsea's toughest remaining fixture - can Jose Mourinho help derail his old side's title hopes? Michael Cox looks at the tactics, and Alan Thompson focuses on the betting...
"This seems likely to be a cautious, defensive-minded and potentially scrappy game."
Manchester United v Chelsea
Live on Sky Sports 1
Match Odds: Manchester United 2.89/5, Chelsea 3.02/1, The Draw 3.211/5.
After two failed attempts to beat his former aide at Stamford Bridge this season, Jose Mourinho will hope to finally defeat Chelsea at Old Trafford on Easter Sunday.
His previous meeting with Chelsea, a 1-0 FA Cup defeat after Andre Herrera's early red card, was notable for his unusual strategy which involved Phil Jones and Matteo Darmian playing at full-back but moving inside and essentially man-marking Eden Hazard and Willian. It briefly caused Chelsea problems, even if it often ended up with United looking like they were using a 6-3-1 formation. Mourinho may turn to that approach once again here.
But this time, Chelsea know what's coming and therefore Antonio Conte may pre-emptively change system and play a 3-5-2, rather than the 3-4-3 which has become Chelsea's default system this season.
That would be a defensive shift, but this could make sense considering Chelsea would probably be content with a point here. Their run-in is remarkably simple, and a draw would keep them on track for the title, so expect the Blues to play cautiously at Old Trafford.
Conte is unlikely to make any surprise selections, but the key is in midfield, where Conte's XI should reveal the formation he's using. His use of Cesc Fabregas against Manchester City meant Chelsea were vulnerable to the movement of David Silva between the lines, and against the threat of Henrikh Mkhitaryan or Juan Mata, it would make sense to deploy the more defensive Nemanja Matic alongside N'Golo Kante. Fabregas' best hope of playing would therefore be as a third central midfielder, which would in turn mean Hazard playing as a second striker, just off Diego Costa.
Expect Chelsea's wing-backs to be more cautious than usual here. Marcos Alonso and Victor Moses have been hugely impressive going forward this season, but will probably sit back and form something of a back five alongside Cesar Azpilicueta, David Luiz and Gary Cahill. Kurt Zouma has been used at the back, but hasn't looked 100% fit and Conte might decide that easing him in next season - or, indeed, when this season's title is already won - is a better bet.
For Manchester United, Mourinho's intentions will be revealed according to the nature of his central midfield zone. Last weekend at Sunderland he played all three of Ander Herrera, Marouane Fellaini and Paul Pogba. That seemed overwhelmingly functional and he can surely afford to drop one of them for an extra attacking player. This is Mourinho, though, and against a Chelsea side potentially featuring a beefed-up midfield, expect him to be cautious.
Zlatan Ibrahimovic will lead the line and battle against his former PSG teammate David Luiz, but will need support with running in behind from teammates. Jesse Lingard doesn't really provide that, nor does Mata or Mkhitaryan, so Anthony Martial or Marcus Rashford could be fielded on the left.
Chelsea's right side of the defence has often seemed vulnerable to an aerial threat this season, so United may look to hit crosses towards a forward breaking inside from the left.
Alternatively, however, if Mourinho replicates his curious strategy from that FA Cup meeting at Stamford Bridge, it will probably mean Antonio Valencia and Ashley Young out wide, and Ibrahimovic remaining extremely isolated upfront.
With that in mind, this seems likely to be a cautious, defensive-minded and potentially scrappy contest. I'll back under 1.5 goals at 3.211/5, as I think the opening goal could win this game.