Liverpool v Tottenham
Live on Sky Sports Premier League
Match Odds: Liverpool 1.654/6, Tottenham 6.05/1, The Draw 4.3100/30.
The most exciting game of the Premier League weekend takes place at Anfield, where top-of-the-table Liverpool face a Tottenham side now desperately battling for a Champions League place, having collected just one point from their last four matches.
Alexander-Arnold the major doubt for Liverpool
Having used a 4-2-3-1 formation regularly a couple of months ago, Jurgen Klopp is now fixated on 4-3-3. Alisson will start behind a defence probably comprising Alexander-Arnold, Joel Matip, Virgil van Dijk and Andy Robertson. If Alexander-Arnold is out, Milner could drop back from midfield to play at full-back.
He's more likely to start in midfield, however, alongside Fabinho and Gini Wijnaldum. Adam Lallana has started Liverpool's last two Premier League games, but against an all-action Tottenham side, Klopp might go for his most energetic midfield trio. Keita will probably miss out, even if fit.
Upfront it's the usual trio of Sadio Mane, Roberto Firmino and Mohamed Salah. Mane is continuing to bang in the goals even as Liverpool have slightly slumped. Firmino has been quieter but did assist Mane's opener against Fulham. Salah is enduring something of a drought but is still looking lively and creating chances for teammates.
Spurs might be forced into a change of shape
Mauricio Pochettino's team selection will be more influenced by injury problems. Eric Dier pulled up when on England duty and is out, as is Serge Aurier. Harry Winks is considered doubtful, with Kyle Walker-Peters also unlikely to take part.
This means that Kieran Trippier will probably start on the right of a four-man defence, and while he continues to offer good overlapping and a crossing threat, he's often been exposed by speedy wingers this season. Up against Mane, perhaps the Premier League's in-form wide forward, this could be a serious problem for Spurs.
Toby Alderweireld and Jan Vertonghen remain arguably the most solid centre-back pairing in the league, while Danny Rose will probably be favoured over Ben Davies at left-back, as Rose's superior pace is better for stopping Salah. Hugo Lloris, who endured a difficult game in the reverse fixture at Wembley, will be in goal.
Pochettino will be desperately hoping that Winks is fit to start in the holding role, because otherwise he's lacking options in central midfield and may be forced to use Davinson Sanchez, switching to a three-man defence which might leave Spurs vulnerable to Liverpool's pace out wide.
Alli could start at the top of a diamond
If fit, Winks will probably play at the base of a diamond with Moussa Sissoko to the right and Christian Eriksen to the left. Winks' calm, assured passing quality will be tested against an energetic Liverpool side, but few players are better at receiving the ball with confidence under pressure.
Dele Alli should be fielded in the number 10 position and will look to make runs in behind Harry Kane and Son Heung-min. The pair have a fine partnership with Kane coming deep towards play and hitting clever passes around the corner, and Son using his speed to sprint into the channels. Their battle against Van Dijk, the Premier League's outstanding defender this season, should be fascinating.
I can't help thinking that Mane against Trippier will be a huge mismatch, and as others have struggled to continue firing in the second half of the season, Mane has improved his goalscoring return. 11 goals in his last 11 Liverpool games means Mane looks good value top open the scoring at 6.05/1.