Wins for Everton, Aston Villa, Arsenal, Man Utd, and Southampton have major implications at both ends of the table. Mike Norman brings us the In-Play odds matched from today's Premier League action...
Almost 12 months after securing a 4-4 draw at Old Trafford - a result that many viewed as the reason Manchester United didn't win the Premier League - Everton have effectively handed Sir Alex Ferguson's men the title by beating Manchester City 2-0 today.
And just a few hours after that result United opened up a 15 point gap at the top of the table with a 1-0 victory over Reading.
Everton were booed off after losing 0-3 at home to Wigan last weekend but it was a completely different atmosphere when the final whistle sounded at Goodison Park in the early kick-off.
Leon Osman put The Toffees ahead with a fantastic drive from outside the box in the first half but Everton's task was seemingly made more difficult when Steven Pienaar received his marching orders for two bookable offences. However, a late Nikica Jelavic goal sealed the win for David Moyes' men meaning City's title defence is all but over.
Everton were matched at 4.1n/a for the win, while the 2-0 Correct Score was matched at a high of 30.029/1 In-Play. Osman was backed at 28.027/1 to open the scoring prior to kick-off.
In the early evening kick-off United were far from at their best in beating Reading, but the 1-0 scoreline - matched at 20.019/1 - is enough to all but mathematically give the Red Devil's their 20th legue title. Wayne Ronney was matched at 5.24/1 to score first before getting the only goal of the game.
Elsewhere today Aston Villa took a giant step to relegation safety with an entertaining 3-2 victory over bottom-of-the-table QPR.
Jermaine Jenas - matched at 40.039/1 to score first - put Rangers in front but they were pegged back right on the stroke of half-time meaning those who backed them at 1.031/33 in the Half Time market were left with burnt fingers.
But in an exciting second half it was Paul Lambert's men who prevailed (matched at 8.615/2 to win the game) with the 3-2 Correct Score being matched at 55.054/1.
Staying towards the bottom of the table, Southampton sprung a minor surprise by beating Liverpool 3-1 at St Mary's. The Saints were matched at 4.94/1 to take the three points, while Morgan Schneiderlin touched a high of 50.049/1 before opening the scoring. The 3-1 Correct Score was backed at 55.054/1.
Arsenal recorded their second 0-2 victory of the week by beating Swansea at the Liberty Stadium. In what turned out to be another huge price first goalscorer - the biggest of the day in fact - Gunners' full-back Nacho Monreal (70.069/1) made the breakthrough late in the second half.
Gervinho scored in injury time to wrap up the victory; the 0-2 Correct Score being matched at 22.021/1.
In the day's other game Stoke and West Brom played out a dull 0-0 draw at the Britannia Stadium - the scoreline never touching higher than 10.5n/a In-Play.
At the bottom of the table three clubs - QPR, Reading, and Wigan - are starting to get cut adrift from the others and are not surprisingly strong favourites in the Relegation market - available to back at 1.211/5, 1.091/11, and 1.695/7 respectively.