Steven Fletcher, Anderson and Gareth Bale will all be big losses for their club's this weekend...
Steven Fletcher - Sunderland v Chelsea (Saturday, 15:00)
When your team has only recorded two victories from their opening 14 Premier League matches, the very last thing you need is an injury to your top scorer. Unfortunately for the under-fire Martin O'Neill, this is exactly the situation he faces, as Sunderland could line up against Chelsea at the Stadium of Light without Steven Fletcher. The Scotland striker is a major doubt for Saturday's game after limping out of the Black Cats' defeat to Norwich with an ankle injury. Raised eyebrows accompanied Fletcher's reported £14 million fee this summer though six league goals - out of the measly 13 Sunderland have managed in total - have more than justified the hefty price. Without him, Sunderland look set to struggle yet further.
Recommended Bet: Back Chelsea to win to nil @ 3.02/1
Anderson - Man City v Man United (Sunday, 13:30, Sky Sports 1)
After scoring a vital goal to get United back into last Saturday's 3-4 thriller at the Madejski, the unfortunate Anderson had to hobble off with a hamstring problem just before the break. He'll now miss the busy Christmas period, starting with this most crucial of Manchester derbies. Even more frustratingly for the Brazilian was the fact he had just forced his way back into the starting line-up at Old Trafford - starting back-to-back league games for the first time this season - after three months without starting one. Although United possess Michael Carrick and Darren Fletcher, neither man offers quite the same dynamism going forward as Anderson, who can also be relied upon to track back.
Recommended Bet: Back Man City and Man United to draw @ 3.65n/a
Gareth Bale - Everton v Tottenham (Sunday, 15:00)
Tottenham are on a role at present, having racked up three consecutive Premier League victories to put themselves in pole position to challenge for a top-four spot. One of Spurs' obvious strengths is their ability to attack at pace from wide areas using two of the divisions swiftest wingers in Aaron Lennon and Gareth Bale. The Welshman has been arguably the best performer in the Premier League in recent weeks, scoring three goals from his last four starts and regularly motoring past people with consummate ease. One of Bale's few flaws is his susceptibility to injuries and in particular hamstring troubles which again saw him limp off in Tottenham's last league victory over Fulham. Opposing teams are bound to get a lift when they see his name missing from the teamsheet.
Recommended Bet: Back Everton and Tottenham to draw at 3.613/5