Phil Neville - Everton v Norwich (Saturday, 15:00)
Everton stalwart and skipper Phil Neville will be out for six to eight weeks after undergoing knee surgery. This is a bitter blow to David Moyes whose already paper-thin squad is stretched to the limits with ongoing injuries to Darren Gibson and Tony Hibbert. Everton's lack of central midfielders had already prompted Moyes to bring in journeyman Thomas Hitzlsperger on a quick-fix deal and young Ross Barkley was recalled from a loan spell to help out before the manager can make any January acquisitions. Saturday's loss to Reading isn't as much of a shock when you consider they played with a makeshift pairing of Hitzlsperger and Leon Osman.
Recommended Bet: Back both teams to score @ [1.81]
Yohan Cabaye - Southampton v Newcastle (Sunday, 15:00)
Newcastle are another team who have seen an influential player forced to go under the surgeon's knife. Cabaye will be out for several weeks following an operation on a groin injury. His absence has already been felt in the north east as Newcastle succumbed to a shock 2-1 home defeat to Swansea in the Premier League last weekend. The diminutive midfielder is so often the instigator of Newcastle's attacks with his wonderful range of passing and the Magpies looked short of ideas without him. As we saw against Liverpool and Sunderland recently, he has an eye for goal too, which is vital in a team which is struggling to find the net at present.
Recommended Bet: Back Southampton to beat Newcastle @ [2.5]
Vincent Kompany - Chelsea v Manchester City (Sunday, 16:00, Sky Sports 1)
This is potentially the biggest loss for any of the teams this weekend as Vincent Kompany is arguably the best defender in the Premier League. The popular Belgian is a major doubt ahead of the champions' trip to Chelsea as the City skipper left the Etihad Stadium on crutches following their midweek draw with Real Madrid. Kompany has only missed one league game this term as City have steadily worked their way back to the top ahead of their date with Chelsea. City's record at Stamford Bridge is not favourable either - six losses in seven visits - and, without the marshalling powers of their leader, Chelsea's forward line will receive a significant boost.
Recommended Bet: Back Chelsea to beat Manchester City @ [2.66]