West Brom almost down, Stoke have mountain to climb
West Brom's failure to hold on to a one-goal lead at home to fellow strugglers Swansea means that their relegation to the Championship has almost become an inevitability, and even the minimum odds of 1.011/100 were soon snapped up on the Betfair Exchange.
The Baggies looked a more assured outfit in the first half under caretaker manager Darren Moore but their old failings came back to haunt them when they allowed Tammy Abraham to head home in the 75th minute.
Opta Stat: West Bromwich Albion have lost 26 points from winning positions in the Premier League this season, the most by a club in a single campaign since the 2012-13 season (Southampton 29 and Aston Villa 28).
Down the road in the Potteries it was a similar story. Stoke, while resolute against Spurs for 45 minutes, capitulated after Christian Eriksen found the back of the net. Harry Kane also returned to action for Tottenham and - in his opinion - scored their second goal however the Premier League would go on to award it to Eriksen.
As a result, Paul Lambert's side find themselves now 1.282/7 for relegation while Spurs are as short as 1.031/33 to be playing Champions League football next season.
United comeback puts title celebrations on hold
After 30 minutes in this latest edition of the Manchester Derby, all was right with the world, we'd had the thundering Vincent Kompany header, another midfield masterclass from David Silva and a sublime finish from İlkay Gündoğan. 2-0 Man City, half-time, champagne on ice.
But whatever Jose Mourinho said at half-time in the away dressing room, it sparked what has at times this season been a thoroughly lifeless Manchester United side, back into action. Matched as high as 140.0139/1 during the break, Paul Pogba dragged United kicking and screaming back into the game with a two minute salvo to bring the Red Devils back level.
From there it almost seemed inevitable, Chris Smalling, who was at fault for the first goal turned home an Alexis Sanchez free-kick and David De Gea - so frequently the hero - once again kept his side in the game to record a memorable victory.
Opta Stat: Guardiola lost a game in which his side was winning by a two-goal margin for the first time since December 2013 in the Champions League - with his Bayern Munich side losing 3-2 to Manchester City having led 2-0.
This won't of course prevent City from lifting the title but you do have to wonder how it will affect them going into the second leg of their Champions League tie against Liverpool on Tuesday. Guardiola's men are 1.51/2 for victory and 5.69/2 to qualify.
Arsenal escape with three points while Conte's downfall continues
Southampton travelled to the Emirates for Sunday's early kick-off in desperate need of points in their bid to beat the drop but were denied by a Danny Welbeck brace.
The Saints were certainly deserving of more, having gone ahead through Shane Long in the 17th minute and fought their way back from 2-1 down through Charlie Austin but this was not to be their day.
Opta Stat: Mark Hughes has now lost each of his 11 trips to Arsenal in the Premier League, only Harry Redknapp against Manchester United (15) is on a longer wait for an away win against an opponent in the competition.
With Arsenal running out 3-2 winners, Mark Hughes' side are now 2.0621/20 for relegation; they welcome Chelsea to St Mary's next Saturday for which they're currently 4.67/2 outsiders.
How long that price holds is anyone's guess though as Chelsea gave away a first-half lead to West Ham on Sunday afternoon. Chicharito's 73rd minute equaliser means Antonio Conte has won just one of his last five games at the Chelsea helm and are now 26.025/1 to finish in the top four.
Opta Stat: This was the fourth time Hernandez has appeared as a substitute at Stamford Bridge in the Premier League and the Mexican has found the net in all four of those games (four goals).
While his future almost certainly lies away from Stamford Bridge, it could well be likely that his departure is fast-tracked off the back of this result, with former Barcelona man Luis Enrique still the 13/8 favourite to be the next Chelsea manager on the Betfair Sportsbook.