Southampton v Tottenham (Saturday, 12:45, BT Sport 1)
Tottenham have won their last five Premier League games against Southampton
Spurs are enormously enticing outsiders in this encounter for numerous reasons. In addition to the huge head-to-head advantage, the Lilywhites have triumphed on eight of their 11 league trips to teams below them in the table, suffering just one defeat. On top of that, the Saints have lost four in six at home to top-eight rivals, being conquered five times at St Mary's since the end of November.
Recommended Bet: Back Tottenham to win @ 3.8514/5
Crystal Palace v Hull (Saturday, 15:00)
Palace have kept just one clean sheet in 13 Premier League games since Alan Pardew took charge
It is difficult to criticise a manager who has taken over a relegation-threatened club and won ten of his first 16 matches, but Alan Pardew hasn't got Crystal Palace's defence operating as smoothly as Tony Pulis did. However, their situation isn't as concerning as that of Hull, whose sole away shut out in 13 came at Leicester at the peak of the Foxes' slump. Aston Villa are the only other side that they have kept quiet in 13 outings at all venues, and Villa were so disgusted that they axed Paul Lambert!
Recommended Bet: Back both teams to score @ 2.111/10
West Brom v Liverpool (Saturday, 15:00)
Tony Pulis has never lost a Premier League home game against Liverpool (W3 D3)
The Baggies snapped out of a thoroughly un-Pulis-like run of five reverses in six with a win at Crystal Palace and so approach one of the Welsh tactician's favourite annual tasks - outwitting Liverpool - with renewed confidence. Pulis brought Palace back from 3-0 down last term at home to the Reds, whose Black Country record under Brendan Rodgers is similarly grim. They lost his opening Premier League game as their boss 3-0 at The Hawthorns in August 2012 and were held 1-1 there in 2013/14.
Recommended Bet: Lay Liverpool to win @ 2.0621/20
Arsenal v Chelsea (Sunday, 16:00, Sky Sports 1)
Jose Mourinho has never lost against Arsene Wenger in any competition (W7 D5 L0)
It is surreal that Arsenal start as favourites despite Chelsea being unbeaten in the Premier League since New Year's Day and losing twice all season. Mourinho knows precisely how to neuter Wenger's side and has perfected the formula judging by the Gunners failing to register a shot on target in the reverse fixture. The Blues don't even need the win, so have the option of focussing all energies on locking out their hosts if they wish.
Recommended Bet: Lay Arsenal to win @ 2.486/4