There's a mouth-watering encounter on Monday night but just as appealing are these same-game multi-bets on it, involving a prolific defender and England's golden boy, says Jamie Pacheco...
"But Ramos is more than just a defender; he’s also a prolific goalscorer. His 55 goals for Real Madrid and 15 for country would make plenty of attacking midfielders somewhat envious and he’s scored in each of his last two games for Spain, in a 6-0 win over Croatia and a 4-1 win over Wales."
Spain v England
Monday October 15, 20:45
Live on Sky Sports
We'll never know how Spain would have fared at the World Cup had their coach not announced he had just signed for Real Madrid and been promptly sacked on the eve of the tournament.
What we do know is that Luis Enrique has certainly started off life as their new coach in the best possible way. Three games, three wins, 12 scored and just two conceded.
Crucially, one of those was against England at Wembley (2-1 Spain) and for all of England's improvement under Gareth Southgate, the suspicion remains that against the most technical sides in the world they'll continue to fall a little short.
The record books suggest Spain should win this. On home soil, the last four matches have been wins by 2-0, 2-0, 1-0 and 1-0 over the Three Lions. So does common sense: England may peak in two years' time when the likes of Marcus Rashford and Dele Alli are at their best whereas Spain already have that invaluable mixture of youth and experience already.
All things considered, [1.6] is a pretty good price.
And speaking of experience, there are few players with so many games at the top level under their belts as Sergio Ramos. Its' 159 caps and counting (joint 12th on the list of most capped players) and just short of 450 matches at cub level.
But Ramos is more than just a defender; he's also a prolific goalscorer. His 55 goals for Real Madrid and 15 for country would make plenty of attacking midfielders somewhat envious and he's scored in each of his last two games for Spain, in a 6-0 win over Croatia and a 4-1 win over Wales. He also has three for Real this season. He seems to have taken over penalty duties from Ronaldo at club level and from David Silva at international level so it would certainly be a big bonus for us if Spain were to get one here. Ramos is [6.0] to score anytime.
England have failed to score in each of their last four visits to Spain as we've seen already but it's pretty rare for them to draw a blank these days. There was little in the way of chances in that bizarre 0-0 in Croatia on Friday night played in front of well....no-one, which created a strange atmosphere for all players involved. They've scored at least once in 11 of their last 14 and though an away trip to Spain is certainly one of the toughest fixtures in football, they could well get one here.
Unlike previous managers, Gareth Southgate is pretty attacking and he knows as well as anyone that trying to play for 0-0 here will almost certainly end in disaster. He might as well give it a go.
Spain may be packed with options in forward positions but clean sheets aren't their forte at the moment. It's just three of them in their last 12. Both teams to score is [2.1] and that will do us just fine.
And it's probably not worth being too adventurous in terms of looking for England's possible goalscorer.
Raheem Sterling has a notoriously poor record for England and despite the fact that he's scored England's last two goals, Marcus Rashford looks in slightly poor form at the moment. He had a disappointing game in that comeback 3-2 win for Manchester United at the weekend and wasted England's two best chances in Croatia.
So far it hasn't been the best of seasons or Harry Kane, either. Unusually for him he went five games without scoring for club and country between early and mid-September but scored four in three games in the last month including two in a Premier League game against Huddersfield.
His overall record for England is highly impressive - 19 from 33 matches - and with penalty duties and the odd-free kick also a potential source of goals for him, he rates by far England's best chance. It's not often you get a chance to back the Spurs man at [3.1] to get a goal so we're happy to take it.