Conte's 3-4-2-1 v Armatey
Saturday, 12:30, Live on Sky Sports 1
The loss of N'Golo Kante has hit Leicester City really hard this season, and cruelly it seems that they will miss him more than ever when they travel to his new home this Saturday. Antonio Conte's switch to a narrow 3-4-2-1 formation against Hull City will make that Kante zone - now occupied by an underwhelming Daniel Amartey - the most important area of the pitch.
Chelsea's new shape has allowed Eden Hazard and Willian to play side-by-side in central attacking midfield to create arguably the most dangerous narrow front three in the country. Hull City's three central midfielders failed to make a single interception in their own half, which is testament to the way Diego Costa, Willian, and Hazard overwhelmed them. Kante, weaving through the middle, stole the show from a deeper role because more room was made available to him as Hull tried desperately to drown out the front three.
Leicester can expect something similar to happen this weekend. They average the second lowest possession in the division away from home this season (41.7%), and so Chelsea should comfortably dominate the ball. As they look to feed it into Hazard and Willian, Amartey (1.5 tackles and 1.2 interceptions per match, far fewer than Kante's 4.7 tackles and 4.2 interceptions last season) will probably struggle to stifle their influence.
Back Chelsea to win and over 1.5 goals at 4/5
Coutinho v Fellaini
Monday, 20:00, Live on Sky Sports 1
The most obvious flaw in Manchester United's team this season is central midfield, where Marouane Fellaini remains a defensive liability and Paul Pogba can be prone to roaming too far forward. This could be problematic against the narrow attacking lines of Liverpool, particularly if Jose Mourinho is brave and presses Jurgen Klopp's team high up the pitch.
Philippe Coutinho is the main threat to United's goal, largely because Georginio Wijnaldum and Adam Lallana are out with injuries. He is excellent at roaming unseen into the spaces between the lines, whilst Fellaini is notoriously poor at tracking players who do so. Their head-to-head will be crucial, as long as Mourinho follows the current trend and tries to unsettle Liverpool's rhythm at the back.
Traditionally Mourinho likes to sit deep and absorb pressure in big matches. This could still be successful at Anfield, but if it was to fail then the media would no doubt jump on him for failing to move with the times. Either way, an undisciplined performance from Pogba and Fellaini should provide Klopp with the win.
Back Liverpool to win at 21/20
David Silva v Idrissa Gueye
Pep Guardiola's Manchester City have looked static and disjointed since Kevin de Bruyne's injury, and with Raheem Sterling a doubt for Saturday's game this problem is only likely to worsen. Once again he will be relying on players that have looked out of sorts this season (such as Fernando, Ilkay Gundogan, Leroy Sane, and Jesus Navas), which means that David Silva's creativity will be crucial in unlocking one of the league's best defences.
Ashley Williams and Idrissa Gueye have added much needed defensive steel to Everton, who have conceded fewer goals than any team bar Tottenham this season. The former Aston Villa midfielder has averaged 5.1 tackles per match - more than any other Premier League player. He will be instructed to track Silva closely this weekend, and in a one-on-one scenario should come out on top.
If he does, then City will struggle to get on the scoresheet. Navas and Sane provide too much width when paired together, whilst the timidity of Fernando and Gundogan ensures that City will struggle to build quickly towards the final third. This should be a long and wearying game for the home side.
Back under 2.5 goals at 29/20
Benteke v West Ham's troubled defence
Saturday, 17:30, Live on BT Sport 1
An injury to Sam Byram has made West Ham's defensive problems even worse. Slaven Bilic's side have made three errors leading to goals so far this season, continuing their run of being the most error-prone team in the division (they topped the charts with 14 in 2015/16). Given that confidence is low they will most likely look shaky once again here, which should mean Christian Benteke's aerial threat allows plenty of second balls to drop for Andros Townsend and Jason Puncheon in the box.
Benteke has won 8.1 headers per match this season, which is by far the most in the league. Alan Pardew's direct style of football inevitably uses the Belgian as a fulcrum, with Wilfried Zaha and Townsend acting as traditional wingers that drive towards goal and fling the ball towards their new striker. West Ham will not be comfortable with this.
Although James Collins and Winston Reid may fancy themselves in an aerial duel with Benteke, their disarray at the back means that Palace will find space in the box should they continue to launch the ball forward. The home side's proficiency from set-pieces makes it likely that the Hammers will find themselves camped in their own half for an uncomfortably long time.
Back Palace to win at 23/20