Simeone to mastermind another win
Bet 1: Back Atletico Madrid @ 13/10 - KO 20:00 BST
RB Leipzig were still in the Bundesliga title race when the league resumed, but they won just three of their final eight matches, culminating with a defeat to Dortmund on the final day.
Atletico Madrid, meanwhile, emerged from lockdown in good form - going unbeaten in 11 games, winning seven of them. They have proven to be big match players over the years, with their recent last 16 tie with Liverpool being the latest example.
Experience should prove the difference here, as Diego Simeone's men have been here before, while this is new territory for the Germans. Add in the better recent form of the Spanish club, and the 13/10 looks like a bit of value.
No problems for Sao Paulo
Bet 2: Back Sao Paulo 8/13 - KO 23:15 BST
Sao Paulo begin their Brazilian Serie A campaign tonight, so while there isn't much recent form to go on, it would appear likely that they will be good enough to beat Fortaleza.
The visitors lost 2-0 at home to Atletico PR in their season opener on Saturday, and they were defeated by Sao Paulo in both of their meetings last term.
Fernando Diniz's hosts were pretty strong at home last year, and they won six of their last eight on their own patch.
Take the home win in Brazil
Bet 3: Back Internacional @ 5/6 - KO 23:30 BST
Santos finished as runners-up to Flamengo last season, but they have performed poorly in their State League since, and they could only draw 1-1 at home to Bragantino on their return to Serie A action on Sunday.
Tonight they travel to an Internacional side who won their opener - a 1-0 success at Coritiba, and they did much better in their State League. They lost just twice at home last year, while today's opponents were beaten in seven of their 19 on the road.