Manchester City are now as short as 3.39/4 to win this season's FA Cup after easing past Cardiff 2-0 on Sunday afternoon, but the big surprise was Liverpool's exit at the hands of West Brom on Saturday.
While League One outfit Wigan got the better of West Ham on the same day, the Latics actually started the game as favourites to win so from a betting perspective there was no real surprise in the victory for Paul Cook's men, meaning it was Jurgen Klopp's Reds that suffered the most surprising reversal of round four.
Liverpool - who lost at the same stage of the competition last season to Championship side Wolves - were aiming to bounce back from a dismal display in losing to Swansea in the Premier League on Monday night.
But despite starting the match at odds of just 1.282/7, and taking the lead through a sublime Roberto Firmino chip, Klopp's men were all over the place defensively and trailed 3-1 at the interval thanks to two goals from Jay Rodriguez and a Joel Matip own goal.
Mo Salah reduced the arrears with a little over 10 minutes remaining but Liverpool couldn't find an equaliser meaning they lost at Anfield for the first time since 23 April last year.
The Baggies can be backed at 50.049/1 to go on and lift the trophy.
Man City's comfortable win at Cardiff came courtesy of two first half goals by Kevin De Bruyne and Raheem Sterling.
Tottenham survive huge scare but United and Chelsea progress
Newport County nearly produced one of the biggest FA Cup shocks in history when they led Premier League giants Tottenham 1-0 with just under 10 minutes remaining at Rodney Parade.
Despite having home advantage the League Two side went off as massive 16/1 underdogs, but Padraig Amond's header just after half an hour gave them what was then a deserved lead.
Spurs were much improved in the secnd half however and deservedly equalised late in the game when Harry Kane tapped home to deny Mike Flynn's side a history-making win. Tottenham can be backed at 6.411/2 to lift the trophy in May.
Manchester United, 4.84/1, and Chelsea, 6.05/1, go into round five after comfortable wins over Yeovil Town and Newcastle respectively, the Red Devils winning 4-0 on Friday night with Alexis Sanchez making his United debut, while the Blues got the better of their Premier League opponens 3-0 on Sunday afternoon.
To Win the FA Cup
- Man City 3.39/4
- Man Utd 4.84/1
- Chelsea 6.05/1
- Tottenham 6.411/2
- BAR 15.014/1
*Odds correct as of 6pm Sunday 28 January