Cardiff 2.186/5 v Wigan 3.711/4; The Draw 3.55/2
Although it's a full seven days away you have to wonder if Ole Gunnar Solskjaer will have one eye on next week's Premier League six-pointer will Hull at the Cardiff City Stadium. With Tottenham, Everton, and Liverpool to come in their next five matches, Cardiff's next two home league games are absolutely vital, the second of those being against Fulham.
So the thinking is that Solskjaer will rest a few of his first-team regulars, not so much because of tiredness but more because of the fear of injury or suspension - he can ill-afford to go into a crucial stretch of the season with a depleted squad.
That might just level this game up in terms of ability on the field as I'm confident Wigan will be at full strength and raring to 'give it a go'. Remember, the Latics are the current holders of the FA Cup and they won't want to give it up lightly.
Uwe Rosler's men have been in decent form in the Championship, losing just two of their last 11 games, while in this competition they already have a Premier League scalp after beating Crystal Palace - albeit on home soil - in the previous round.
This is definitely a difficult game to call purely because I believe the two sides are much more evenly matched than the markets suggest. I for one can't split them and will back the draw.
In terms of goals I'm not so sure. If the game is to finish level then I don't expect it to be a high-scoring draw so a wager on Under 2.5 Goals is also advised.
Back The Draw @ 3.55/2
Back Under 2.5 Goals @ 1.84/5
Sheffield Wednesday 2.0811/10 v Charlton 4.1; The Draw 3.45
The Owls have been in terrific form in the league and cup, going on a run of 11 games unbeaten, the majority of those under the guidance of caretaker boss Stuart Gray.
That form promoted the Wednesday board to give Gray the job on a permanent basis, though the former Southampton boss suffered his first defeat in midweek when Wigan went to Hillsborough and won 0-3 despite a decent performance from Gray's men.
Wednesday are now nine points clear of the relegation zone and they have momentum on their side so I don't envisage for one moment they'll have any problems avoiding the drop, which hopefully means they'll approach this game in confident mood and with a relatively full strength side.
The same can't be said for Charlton. The Addicks have lost four on the spin now and are the side that occupy that last relegation spot. How Chris Powell will approach the game is anyone's guess - does he send his best side out in the hope they can find some form, or does he rotate his squad with a view to freshening up some of his regulars?
Either way I have a hunch for goals in this game. Wednesday have averaged exactly three goals per game in all competitions at Hillsborough this term so the Over 2.5 Goals option will undoubtedly appeal to some, including myself.
I also think the Owls will be the side scoring the majority of the goals scored and therefore I'll back the home team to make it into the FA Cup sixth round.
Back Sheffield Wednesday to Win @ 2.0811/10
Back Over 2.5 Goals @ 2.245/4
Sheffield United 3.55/2 v Nottm Forest 2.35/4; The Draw 3.45
Forest are one of the country's most in-form sides. Billy Davies' men are unbeaten in 16 league and cup games and they're yet to concede a goal in this competition.
The slight worry is that Forest face Championship leaders Leicester in midweek and therefore we might not see them at full strength at Bramall Lane on Sunday afternoon, but with the Blades embroiled in a relegation fight in League One, they could take the opportunity to rest a few players also.
There will be many who will take the view that if Sheff United can go to Premier League side Fulham and come away with the win then they'll be able to match Championship side Forest. But there's a huge difference between losing games - like Fulham were doing - and winning games like the Nottingham side are.
In other words, Forest are full of confidence, whereas the Cottagers weren't, and I suspect Sheff United won't have much confidence either going in to this tie. Davies' men have lost just two of 15 league games on the road this season and I don't seem them losing this cup match either, in fact I fancy them strongly to take the win.
Back Nottm Forest to Win @ 2.35/4